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Keep in mind that most users will not need to use the 5v setting on the Grove connector jumper. The Mayfly is not tolerant of 5v I/O signals, so any peripheral devices you connect must not send any voltage greater than 3.3v back to the Mayfly I/O pins. The 5v options is only there for experienced users who can ensure that they have proper level-shifting circuitry or other protective measures to ensure that the Mayfly only sees 3.3v signals. In my case, I use several analog sensors that need to be powered by 5v supply, but only output a 0-2.5v signal. Other digital sensors that require 5v will be connected to a level-shifting adapter board via the Grove connector.